Reply to Arends and Harkisoen
نویسندگان
چکیده
TO THE EDITOR—We thank Arends and Harkisoen [1] for their thoughtful comments relating to our article on the efficacy of polyspecific intravenous immunoglobulin (IVIG) in streptococcal toxic shock syndrome (STSS). As detailed in our article [2], 75 STSS patients were identified through a national Swedish active surveillance study of invasive group A streptococcal (GAS) infections, in which a total of 746 invasive cases were included [3]. The study was designed to focus entirely on STSS cases and not on the heterogeneous group of patients with invasive (GAS) infections, the rationale being that IVIG has been suggested as adjunctive therapy in STSS with a beneficial effect on survival in these patients with pronounced systemic toxicity. The mortality often exceeds 40% in STSS cases compared with <15% for invasive cases. Among the 746 invasive GAS cases, 26 patients in total received IVIG, and as expected, the vast majority had an STSS diagnosis (n = 23).
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عنوان ژورنال:
دوره 60 شماره
صفحات -
تاریخ انتشار 2015